Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho
作者： Yan Zhou , Yuan Su , Baolin Li , Feng Liu , John W Ryder
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摘要: A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to preferentially reduce the secretion highly amyloidogenic, 42-residue amyloid-beta peptide Abeta42. We found that Rho and its effector, Rho-associated kinase, regulated amount Abeta42 produced in vitro only those NSAIDs effective as inhibitors lowered Administration Y-27632, a selective Rock inhibitor, also brain levels transgenic mouse model Alzheimer's disease. Thus, Rho-Rock pathway may regulate amyloid precursor protein processing, can through inhibition activity.
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