Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats.
作者： Perumal Subramanian , Shankaran Mirunalini , Seithikurippu R. Pandi-Perumal , Ilya Trakht , D.P. Cardinali
DOI: 10.1016/J.EJPHAR.2007.06.011
关键词:
摘要: This study examines the effect of a daily administration melatonin for 45 days at two doses (0.5 and 1.0 mg/kg body wt.) on antioxidant status, lipid peroxidation profile in brain liver rats. Both caused significant decrease levels cholesterol, phospholipids, triglycerides free fatty acids examined tissues. Concomitantly, treatment with augmented activity enzymes superoxide dismutase, catalase glutathione peroxidase as well increased levels. These results offer support to hypothesis that pharmacological amounts effectively reduces oxidative stress acts an antihyperlipidemic agent.
elsevier.com
sci-hub.se 参考文章(35)
I. Túnez, M. C. Muñoz, M. Feijoo-López, E. Valdelvira, I. Bujalance-Arenas, P. Montilla, Effect of melatonin on hyperlipidemic nephropathy under constant light exposure. Journal of Physiology and Biochemistry. ,vol. 58, pp. 109- 114 ,(2002) , 10.1007/BF03179846
Marta Hoyos, Juan M. Guerrero, Ramon Perez-Cano, Josefina Olivan, Fernando Fabiani, Antonio Garcia-Pergañeda, Carmen Osuna, Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. Journal of Pineal Research. ,vol. 28, pp. 150- 155 ,(2002) , 10.1034/J.1600-079X.2001.280304.X
Albert Zlatkis, Albert Zlatkis, Albert J. Boyle, Albert J. Boyle, Bennie Zak, Bennie Zak, A new method for the direct determination of serum cholesterol. Journal of Laboratory and Clinical Medicine. ,vol. 41, pp. 486- 492 ,(1953) , 10.5555/URI:PII:0022214353901255
P N Viswanathan, Poonam Kakkar, Ballabh Das, A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics. ,vol. 21, pp. 130- 132 ,(1984)
B Malpaux, P Chemineau, H Tricoire, M Møller, Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod Reproduction in domestic ruminants V. Proceedings of the Sixth International Symposium on Reproduction in Domestic Ruminants held in Crieff, Scotland, UK, August 2002. ,vol. 61, pp. 311- 321 ,(2003)
Russel J Reiter, Dun-xian Tan, M Pilar Terron, Luis J Flores, Zbigniew Czarnocki, Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. Acta Biochimica Polonica. ,vol. 54, pp. 1- 9 ,(2007) , 10.18388/ABP.2007_3264
M.K. Vaughan, B.A. Richardson, C.M. Craft, M.C. Powanda, R.J. Reiter, Interaction of Ageing, Photoperiod and Melatonin on Plasma Thyroid Hormones and Cholesterol Levels in Female Syrian Hamsters (Mesocricetus auratus) Gerontology. ,vol. 28, pp. 345- 353 ,(1982) , 10.1159/000212555
D. Mullerwieland, B. Behnke, K. Koopmann, W. Krone, Melatonin Inhibits LDL Receptor Activity and Cholesterol-Synthesis in Freshly Isolated Human Mononuclear Leukocytes Biochemical and Biophysical Research Communications. ,vol. 203, pp. 416- 421 ,(1994) , 10.1006/BBRC.1994.2198
R. Reiter, Regina Carneiro, C.-S. Oh, Melatonin in Relation to Cellular Antioxidative Defense Mechanisms Hormone and Metabolic Research. ,vol. 29, pp. 363- 372 ,(1997) , 10.1055/S-2007-979057
Joaquı́n J Garcı́a, Russel J Reiter, Juan M Guerrero, Germaine Escames, Byung P Yu, Chang S Oh, Antonio Muñoz-Hoyos, Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation FEBS Letters. ,vol. 408, pp. 297- 300 ,(1997) , 10.1016/S0014-5793(97)00447-X