Wnt Signaling Induces Vulva Development in the Nematode Pristionchus pacificus
作者： Huiyu Tian , Benjamin Schlager , Hua Xiao , Ralf J. Sommer
DOI: 10.1016/J.CUB.2007.12.048
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摘要: Summary The Caenorhabditis elegans vulva is induced by a member of the epidermal growth factor (EGF) family that expressed in the gonadal anchor cell, representing prime example of signaling processes animal development [1]. Comparative studies indicated induction has changed rapidly during evolution [2]. However, nothing was known about molecular mechanisms underlying these differences. By analyzing deletion mutants five Wnt pathway genes, we show induces formation Pristionchus pacificus . A Ppa-bar-1/β -catenin completely vulvaless. Several ligands and receptors act redundantly induction, Ppa-egl-20 /Wnt; Ppa-mom-2 Ppa-lin-18 /Ryk triple are strongly differentially somatic gonad, posterior body region, respectively. In contrast, previous Ppa-lin-17 , one Frizzled-type receptors, negative role [3, 4]. We found mutations Ppa-bar-1 suppress phenotype Ppa-lin-17. Thus, an unexpected complexity involved repression P. This study provides first identification inductive signal nematode other than
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