Right into the heart of microRNA-133a

摘要: MicroRNAs play an essential role in diverse cellular processes, such as proliferation, differentiation, apoptosis, and stress response. Recent studies demonstrate that miRNAs are important for timing developmental decisions fine-tuning determination vertebrate heart development. In elegant set of experiments reported this issue Genes & Development, Liu et al. (3242-3254) miR-133a functions inhibitor cardiomyocyte proliferation a modifier serum response factor (SRF)-dependent transcriptional signaling the murine heart. Both targeted deletion transgenic overexpression can result same cardiac phenotype, ventricular septal defect (VSD) failure. The new data add another piece to puzzle regulatory networks implicated disease. It will be interesting see, if is also involved human diseases, especially VSD dilated cardiomyopathy.