Mechanism and stereospecificity of α-hydroxylation of lignoceric acid in rat brain
作者： Kiyoshi Tatsumi , Saood Murad , Yasuo Kishimoto
DOI: 10.1016/0003-9861(75)90010-7
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摘要: Abstract Cerebronic acid (2-hydroxytetracosanoic acid) is the major fatty component of cerebrosides and sulfatides in mammalian brain. Our previous communication demonstrated synthesis cerebronic from lignoceric (tetracosanoic by a rat brain preparation presence molecular oxygen reduced pyridine nucleotide (Hoshi, M., Kishimoto, Y. (1973) J. Biol. Chem. , 248 4123–4130). The present'studies on conversion ( RS )-[2- 3 H]-, )-[3- R S H]lignoceric acids to preparations establish that pro- hydrogen at α-carbon replaced hydroxyl group with overall retention configuration.
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