Reduced serum amino acid concentrations in infants with necrotizing enterocolitis.
作者： Randy M. Becker , Guoyao Wu , Joseph A. Galanko , Wunian Chen , Angela R. Maynor
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摘要: Abstract Objective: To determine whether premature infants who have necrotizing enterocolitis (NEC) deficiencies in glutamine (GLN) and arginine (ARG), which are essential to intestinal integrity. Study design: A 4-month prospective cohort study of serum amino acid urea levels was done. Serum were measured by high-pressure liquid chromatography enzymatic methods, respectively, on samples obtained days life 3, 7, 14, 21. Results: Infants the control (n = 32) NEC groups 13) comparable for birth weight, gestational age, Apgar scores. began mean day 14.5 (95% CI, 11 18). Median values GLN 37% 57% lower group 21 compared with those ( P Conclusions: selective including reduced ARG that may predispose illness. (J Pediatr 2000;137:785-93)
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