Association of homeostasis model assessment of insulin resistance, adiponectin, and low-grade inflammation with the course of the metabolic syndrome

摘要: Abstract Objective We examined the association between insulin resistance (IR), adiponectin, and inflammation markers development of metabolic syndrome (MetS). Furthermore, we aimed to establish relationship IR, serum parameters chronic inflammation. Methods MetS was assessed in 1628 Kazakh participants (768 men; 860 women) Xinjiang, Northwestern China. Results Adiponectin, homeostasis model assessment IR (HOMA-IR), interleukin-6 (IL-6), C-reactive protein (CRP) remained significantly associated with after further adjustment for sex, age, smoking status, low-density lipoprotein cholesterol, total high-density cholesterol. Moreover, HOMA-IR, IL-6, CRP increased concurrently an number components, inverse trend adiponectin components found. The median IL-6 HOMA-IR from lowest highest quartile. In contrast, remarkably decreased quartile ( P Conclusion strengthen notion that inflammatory can predict course MetS. our results suggest a state might be IR.