Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA (“Ecstasy”) and MDA (“Love”)

摘要: Abstract The present study determined the effect of caffeine co-administration on core body temperature response and long-term serotonin (5-HT) loss induced by methylenedioxymethamphetamine (MDMA; “Ecstasy”) its metabolite methylenedioxyamphetamine (MDA; “Love”) to rats. In group-housed animals, (10 mg/kg) enhanced acute toxicity MDMA (15 mg/kg) MDA (7.5 mg/kg), resulting in an exaggerated hyperthermic (+2 °C for 5 h following +1.5 °C 3 h MDA) when compared (+1 °C 3 h) 1 h) alone. Co-administration with or was also associated increased lethality. To reduce risk lethality, doses were reduced further experiments animals housed individually. examine effects repeated administration, received (5 mg/kg) without twice daily 4 consecutive days. alone hypothermia (fall 1 2 °C) over treatment resulted hyperthermia (increase up 2.5 °C) administration treated MDMA/MDA This not observed unlike + MDA, where obtained 4 day period. addition, 4 weeks after last treatment, (but MDMA) a reduction 5-HT 5-hydroxyindole acetic acid (5-HIAA) concentrations frontal cortex (to 61% 58% control, respectively), hippocampus (48% 60%), striatum (79% 64%) amygdala (63% 37%). However, (2.5 mg/kg) co-administered four times 2 days both hippocampal (reduced 68% control). Neither nor significant regional 5-HIAA administration. conclusion, promotes MDA. is serious drug interaction, which could have important health consequences recreational users.