Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia‐Induced Neural Stem/Progenitor Cells After Cerebral Infarction

摘要: Transplantation of neural stem cells (NSCs) has been proposed as a therapy for range neurological disorders. To realize the potential this approach, it is essential to control survival, proliferation, migration, and differentiation NSCs after transplantation. are regulated in vivo, at least part, by their specialized microenvironment or "niche." In adult central nervous system, neurogenic regions, such subventricular subgranular zones, include residing vascular niche with endothelial cells. Although there accumulating evidence that promote proliferation vitro, no description impact on transplanted NSCs. study, we grafted cortex-derived stroke-induced stem/progenitor cells, obtained from mice, onto poststroke cortex presence absence compared neuronal precursors vivo. Cotransplantation increased survival ischemia-induced also accelerated transplantation alone. These data indicate reconstitution elements enhances progenitor