Microscopic imaging techniques for drug discovery

摘要: Microscopic imaging can enhance the drug discovery process by helping to describe how disease processes unfold and potential therapies might intervene. Recently introduced technologies, enhancements existing techniques, are addressing technical issues that have limited usefulness of microscopic in past. In particular, these innovations improving spatial resolution, increasing tissue penetration, overcoming physical access enhancing experimental throughput. Notable recent trends, which discussed this article, include development super-resolution microscopes, incorporation multiphoton techniques into intravital fibre-optic microscopy automation image analysis for high-content screening. Together, developments augmenting assays models used early and, some cases, enabling new ones.