Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

摘要: Tumors use several strategies to evade the host immune response, including creation of an immune-suppressive and hostile tumor environment. Tissue hypoxia due inadequate blood supply is reported develop very early during establishment. Hypoxic stress has a strong impact on cell biology. In particular, tissue contributes therapeutic resistance, heterogeneity progression. It also interferes with plasticity, promotes differentiation expansion stromal cells, remodels metabolic landscape support privilege. Therefore, been regarded as central factor for aggressiveness metastasis. this regard, manipulating host-tumor interactions in context hypoxic microenvironment may be important preventing or reverting malignant conversion. We will discuss how microenvironment-driven transient compositional involves stress. Tumor concern since it can reduce effectiveness conventional therapies well cancer immunotherapy. Thus, understanding cells respond allow design innovative that overcome these barriers. A better hypoxia-dependent mechanisms involved regulation tolerance could lead new enhance antitumor immunity. discovery validation targets derived from major importance. context, critical hypoxia-associated pathways are attractive immunotherapy cancer. review, we summarize current knowledge regarding molecular induced by special emphasis resistance suppression. emphasize its associated pathways, which development more durable successful approaches future.