Strength over time of a resorbable bioscaffold for body wall repair in a dog model.
作者： Stephen Badylak , Klod Kokini , Bob Tullius , Bryan Whitson
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摘要: The change in strength over time of a biomaterial derived from the small intestinal submucosa (SIS) was determined dog model body wall repair. Full-thickness defects measuring 8 x 12 cm were surgically created and then repaired with multilaminate eight-layer form SIS 40 dogs. Five dogs sacrificed at each following points: 1 day, 4 days, 7 10 1, 3, 6, 24 months. Ball burst tests that measured biaxial ultimate load-bearing capability performed on device prior to implantation device/implant site sacrifice. implant approximately 73 +/- pounds. diminished 18 pounds progressively increased value 156 26 months (P < 0.05). clinical utility degradable such as depends balance between rate degradation host remodeling. Naturally occurring extracellular matrix scaffolds show rapid associated subsequent remodeling tissue exceeds native when used repair device.
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