Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: Relationship to histologic subtypes
作者： B. de Leeuw , R.F. Suijkerbuijk , D. Olde Weghuis , A.M. Meloni , G. Stenman
DOI: 10.1016/0165-4608(94)90191-0
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摘要: Fluorescence in situ hybridization (FISH) and molecular analyses of synovial sarcomas with cytogenetically similar (X;18)(p11.2;q11.2) translocations have revealed two alternative breakpoint regions Xp11.2, one residing the ornithine aminotransferase-like 1 (OATL1) region other related but distinct OATL2 region. As these results were obtained by different groups, we set out to evaluate an extended series tumors special emphasis on possible X-related regions. Together, seven identified a break OATL1 six near OATL2, thereby confirming actual existence Xp We speculate that there seems be relationship between occurrence histologic phenotype tumors, predominance OATL1-related breakpoints classical biphasic OATL2-related monophasic fibrous tumors.
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