HER2 gene status in primary breast cancers and matched distant metastases

摘要: Introduction The status of the gene encoding human EGF-like receptor 2 (HER2) is an important prognostic and predictive marker in breast cancer. Only cancers with HER2 amplification respond to targeted therapy trastuzumab. It controversial what degree primary tumour representative distant metastases terms status. Discrepancies between tumours have been described, but their reasons remain unclear. Here, we compared on cytological specimens result from carcinomas, explored prevalence for discrepant results.