Overexpression of ras is an independent prognostic factor in colorectal adenocarcinoma.
作者： XIAO-FENG SUN , HANNA EKBERG , HONG ZHANG , JOHN M. CARSTENSEN , B. NORDENSKJÖLD
DOI: 10.1111/J.1699-0463.1998.TB01396.X
关键词:
摘要: The expression of ras was investigated by using immunohistochemistry in 245 primary colorectal adenocarcinomas and 49 corresponding metastases the lymph nodes. One hundred forty-four (59%) tumours presented as positive 37 (76%) were metastases. positively related to cell proliferation (p = 0.01) significantly increased with aneuploidy (68%) compared diploidy (51%) tetraploidy (53%, p 0.01). frequency from Dukes' stage A stages B-D (41% vs 62%, 40 paired their metastases, difference did not reach statistical significance (73% 83%, p= 0.32). In survival analyses, overexpression predicted a poor prognosis independent stage, DNA ploidy S-phase fraction 0.049). We find any significant relationship between patients' sex, age, tumour location, growth pattern, differentiation, p53 or heat shock protein. results indicate that alteration may be involved instability cellular overproliferation, but progression advanced development an important biological marker for evaluating patients adenocarcinoma.
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