Synthesis, spectroscopy, single crystal XRD and biological studies of multinuclear organotin dicarboxylates

摘要: Abstract Multinuclear organotin(IV) dicarboxylates of the general formula (Me3Sn)2L·H2O (1), (Ph3Sn)2L (2) and Me2SnL[Sn(Cl)2Me2]2 (3) were synthesized by refluxing disodium iminodiacetate hydrate (Na2L·H2O) with Me3SnCl/Ph3SnCl/Me2SnCl2 in methanol. The elemental analysis (C, H N) data agreed well chemical compositions products. IR spectroscopy demonstrated a bridging coordination mode carboxylate group. 1H NMR suggested penta-coordinated environment around tin(IV) center complexes 1 3. title complex 3 represents one very few examples carboxylates showing simultaneously dimethyltin(IV) as dichlorodimethyltin(IV) moieties, substitution addition reactions, respectively. 13C carboxylate-metal linkages. EIMS ESI spectra verified molecular skeletons products 1–3. Thermogravimetric revealed bimetallic nature 2. A single crystal XRD study has shown predominantly square pyramidal geometry some trigonal bipyramidal characteristics each metal center. novel exhibited antibacterial/antifungal potential their minimal inhibitory concentrations (MIC) also evaluated. In vitro hemolytic studies on human red blood cells indicated slightly toxic complexes.