The history of the "natural history" of hepatitis C (1968-2009).

摘要: In the late 1960's, only types A and B hepatitis were believed to exist, distinguished by circumstances of exposure incubation periods. early 1970's, studies transfusion recipients begun with belief that would be responsible should transfusion-associated develop. After discovery viruses B, neither agent was found responsible, hence non-A, non-B (NANB) hepatitis. Initial follow-up these cases showed approximately 50% developed chronic based on persistence serum enzymes for at least 6 months. Approximately 15 years later, after C virus had been identified as cause NANB hepatitis, develop more frequently indicated persistent viral infection in over 80% infected adults but about children or young women. Follow-up 2 4 decades many persons progressive hepatic fibrosis, sometimes culminating cirrhosis and/or liver cancer. Long-term natural history have proved challenging because disease onset is often silent progression extremely slow. Differing strategies used determine history, descriptions results which are presented this review.