Deletion of chromosome 11p15, p12, q22, q23-24 loci in human prostate cancer
作者： Rajvir Dahiya , Joseph McCarville , Celeste Lee , Weixing Hu , Gurjit Kaur
DOI: 10.1002/(SICI)1097-0215(19970717)72:2<283::AID-IJC14>3.0.CO;2-H
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摘要: Loss of heterozygosity (LOH) on chromosome 11 is frequently altered in various epithelial cancers. The present study was designed to investigate LOH microdissected samples normal prostatic epithelium and invasive carcinoma from the same patients. For this purpose, DNA extracted tumor cells 38 prostate cancers, amplified by polymerase chain reaction PCR analyzed for using 9 different polymorphic markers (D11S1307, D11S989, D11S1313, D11S898, D11S940, D11S1818, D11S924, D11S1336 D11S912). identified 30 cases (78%) with at least one marker. Four distinct regions loss detected were: 1) 11p15, loci between D11S1307 D11S989; 2) 11p12, locus D11S131 (11p12); 3) 11q22, D11S940 D11S1818; 4) 11q23-24, D11S912. We found 25% tumors 11p15; 39% had 11p12; 66% 11q22; 47% 11q23-24. These deletions 11q22 11q23-24 were not related stage or grade tumor. Int. J. Cancer 72:283–288, 1997. © 1997 Wiley-Liss, Inc.
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