A perspective on microarrays: current applications, pitfalls, and potential uses.

摘要: With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly used laboratories around world. In fact, fields as varied as: toxicology, evolutionary biology, drug development production, disease characterization, diagnostics development, cellular physiology stress responses, forensics have benefiting from its use. However, for many researchers not familiar microarrays, current articles reviews often address neither fundamental principles behind nor proper designing experiments. Although, relatively simple, conceptually, practice does require careful planning detailed understanding limitations inherently present. Without these considerations, it can be exceedingly difficult to ascertain valuable data. Therefore, this text aims outline key features technology, paying particular attention applications outlined recent publications, experimental design, statistical methods, potential uses. Furthermore, review meant comprehensive, but rather substantive; highlighting important concepts detailing steps necessary conduct interpret Collectively, included will highlight versatility provide a glimpse what future may hold.