Prediction of duration and success rate of unrelated hematopoietic stem cell donor searches based on the patient's HLA-DRB1 allele and DRB1-DQB1 haplotype frequencies

摘要: Rapid identification of a matched unrelated donor is essential for patients in need hematopoietic SCT. We carried out retrospective evaluation 549 searches (UDSs), which were completed 2005 23 German transplant centers. On the basis patient's HLA-DRB1 allele and DRB1–DQB1 haplotype frequencies, UDSs divided into four groups with different search success probability predictions. For 90.5% patients, an acceptable HLA-matched, 61.6% HLA-A-B-Cw-DRB1-DQB1-identical (10/10 matched) was found. The median duration 22 days. In high (n=318), medium (n=157), low (n=56) very (n=18) UDS probability, found 99.1, 86.6, 75.0 22.2% 10/10-matched 78.3, 49.7, 17.9 4.5% respectively. 20, 27, 45 477 days high, medium, rate can be predicted on HLA-DRB1-DQB1 frequencies. An most even if indication transplantation urgent.