Unrelated Hematopoietic Stem Cell Donor Matching Probability and Search Algorithm
作者： J.-M. Tiercy
DOI: 10.1155/2012/695018
关键词:
摘要: In transplantation of hematopoietic stem cells (HSCs) from unrelated donors a high HLA compatibility level decreases the risk acute graft-versus-host disease and mortality. The diversity system at allelic haplotypic heterogeneity typing data registered render search process complex task. This paper summarizes our experience with algorithm that includes start probability estimate (high/intermediate/low) to identify HLA-A, B, C, DRB1, DQB1-compatible donor (a 10/10 match). Based on 2002–2011 searches about 30% patients have high, an intermediate, 40% low search. Search success rate duration are presented discussed in light other centers. Overall 9-10/10 matched HSC can now be identified for 60–80% European descent. For selected basis DPB1-matching estimated >40%. there is no consensus which incompatibilities more permissive, although HLA-DQB1 mismatches generally considered as acceptable. Models discrimination detrimental based specific amino acid residues rather than alleles presented.
hindawi.com参考文章(38)
M Oudshoorn, I.I.N Doxiadis, P.M van den Berg-Loonen, C.E.M Voorter, W Verduyn, F.H.J Claas, Functional versus structural matching: can the CTLp test be replaced by HLA allele typing? Human Immunology. ,vol. 63, pp. 176- 184 ,(2002) , 10.1016/S0198-8859(01)00384-6
B. Kervaire, A. H. Schmidt, J. Villard, J.-M. Tiercy, Sequence of a novel HLA‐A2 allele in a haematopoietic stem cell donor of the international registry Tissue Antigens. ,vol. 74, pp. 248- 249 ,(2009) , 10.1111/J.1399-0039.2009.01270.X
Lee Ann Baxter-Lowe, Martin Maiers, Stephen R. Spellman, Michael D. Haagenson, Tao Wang, Marcelo Fernandez-Vina, Steven G.E. Marsh, Mary Horowitz, Carolyn Katovich Hurley, HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States. Biology of Blood and Marrow Transplantation. ,vol. 15, pp. 971- 981 ,(2009) , 10.1016/J.BBMT.2009.04.015
K Hirv, K Bloch, M Fischer, B Einsiedler, H Schrezenmeier, J Mytilineos, Prediction of duration and success rate of unrelated hematopoietic stem cell donor searches based on the patient's HLA-DRB1 allele and DRB1-DQB1 haplotype frequencies Bone Marrow Transplantation. ,vol. 44, pp. 433- 440 ,(2009) , 10.1038/BMT.2009.53
Béatrice Pédron, Valérie Guérin-El Khourouj, Jean-Hugues Dalle, Marie Ouachée-Chardin, Karima Yakouben, France Corroyez, Anne Auvrignon, Arnaud Petit, Judith Landman-Parker, Guy Leverger, André Baruchel, Ghislaine Sterkers, Contribution of HLA-A/B/C/DRB1/DQB1 Common Haplotypes to Donor Search Outcome in Unrelated Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation. ,vol. 17, pp. 1612- 1618 ,(2011) , 10.1016/J.BBMT.2011.03.009
Stephen Spellman, John Klein, Michael Haagenson, Medhat Askar, Lee Ann Baxter-Lowe, Jun He, Susan Hsu, Rainer Blasczyk, Carolyn Hurley, Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. ,vol. 18, pp. 739- 746 ,(2012) , 10.1016/J.BBMT.2011.09.008
E. W. Petersdorf, M. Malkki, T. A. Gooley, S. R. Spellman, M. D. Haagenson, M. M. Horowitz, T. Wang, MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation Science Translational Medicine. ,vol. 4, ,(2012) , 10.1126/SCITRANSLMED.3003974
F. Bettens, G. Nicoloso de Faveri, J.-M. Tiercy, HLA-B51 and haplotypic diversity of B-Cw associations: implications for matching in unrelated hematopoietic stem cell transplantation Tissue Antigens. ,vol. 73, pp. 316- 325 ,(2009) , 10.1111/J.1399-0039.2009.01215.X
Florence Bettens, Jakob Passweg, Urs Schanz, Yves Chalandon, Dominik Heim, Tayfun Güngör, Georg Stussi, Grazia Nicoloso, Helen Baldomero, Alois Gratwohl, Jean-Marie Tiercy, Impact of HLA-DPB1 Haplotypes on Outcome of 10/10 Matched Unrelated Hematopoietic Stem Cell Donor Transplants Depends on MHC-Linked Microsatellite Polymorphisms Biology of Blood and Marrow Transplantation. ,vol. 18, pp. 608- 616 ,(2012) , 10.1016/J.BBMT.2011.09.011
Ann Woolfrey, John P. Klein, Michael Haagenson, Stephen Spellman, Effie Petersdorf, Machteld Oudshoorn, James Gajewski, Gregory A. Hale, John Horan, Minoo Battiwalla, Susana R. Marino, Michelle Setterholm, Olle Ringden, Carolyn Hurley, Neal Flomenberg, Claudio Anasetti, Marcelo Fernandez-Vina, Stephanie J. Lee, HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation. Biology of Blood and Marrow Transplantation. ,vol. 17, pp. 885- 892 ,(2011) , 10.1016/J.BBMT.2010.09.012