Posterior parietal cortex contributions to cross-modal brain plasticity upon sensory loss

摘要: Sensory loss causes compensatory behavior, like echolocation upon vision or improved visual motion detection deafness. This is enabled by recruitment of the deprived cortical area intact senses. Such cross-modal plasticity can however hamper rehabilitation via sensory substitution devices. To steer towards desired outcome for patient, having control over take-over essential. Evidence accumulates to support a role posterior parietal cortex (PPC) in multimodal plasticity. shows increased activity after loss, keeping similar functions but driven other Patient-specific factors stress, social situation, age and attention, have significant influence on PPC We propose that understanding response context extremely important determining best possible implant-based therapies, mouse research holds potential help unraveling underlying anatomical, cellular neuromodulatory mechanisms.