Genetic alterations on chromosome 17 distinguish different types of epithelial ovarian tumors.
作者： M PIERETTI
DOI: 10.1016/0046-8177(95)90139-6
关键词:
摘要: Epithelial tumors of the ovary are most common ovarian adult women. They exist in several different histological patterns and exhibit varying degrees aggressiveness. Molecular genetic studies epithelial cancer have shown that loss heterozygosity (LOH) for regions chromosome 17 is a event, probably reflecting inactivation one or more tumor suppressor genes present on this chromosome. We examined 87 sporadic grade type at 16 loci found 35% them showed LOH 17. Of these, 84% all informative markers, suggesting entire homologue may occurred. Interestingly, was observed frequently serous (49%), less endometrioid (15%), rare mucinous (4%) (P = .01 P .0002, respectively). Our findings support concept subtypes be result molecular events.
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