Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.
作者： Christopher T. Walsh , Stuart W. Haynes , Brian D. Ames , Xue Gao , Yi Tang
DOI: 10.1021/CB4001684
关键词:
摘要: Complexity generation in naturally occurring peptide scaffolds can occur either by posttranslational modifications of nascent ribosomal proteins or through post assembly line tailoring nonribosomal peptides. Short enzymatic pathways utilizing bimodular and trimodular synthetase (NRPS) lines, followed oxygenases and/or prenyltransferases, efficiently construct complex fungal peptidyl alkaloid Aspergilli, Neosartorya, Penicillium species. Use the nonproteinogenic amino acid anthranilate as chain-initiating building block chain-terminating intramolecular nucleophile leads to with two seven fused rings.
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