LncRNAs: the bridge linking RNA and colorectal cancer.

摘要: // Yanfei Yang 1, * , Linjie Zhao Lingzi Lei Wayne Bond Lau 2, Bonnie 3, Qilian 1 Xiaobing Le Huiliang 4 Chenlu Wang 5 Zhongyue Luo Yu Xuan Yi Chen 6 Xiangbing Deng Lian Xu 7 Min Feng Tao Xia ,Yuquan Wei Shengtao Zhou Department of Obstetrics and Gynecology, Key Laboratory Birth Defects Related Diseases Women Children Ministry Education, West China Second Hospital State Biotherapy/Collaborative Innovation Center, Hospital, Sichuan University, Chengdu, P. R. 2 Emergency Medicine, Thomas Jefferson University U.S.A 3 Kaiser Permanente Santa Clara Medical Affiliate Stanford Orthopedics, College Life Sciences, Gastrointestinal Surgery, P.R. Pathology, These authors have contributed equally to this work Correspondence to: Zhou, email: taotaovip2005@163.com Keywords: lncRNAs, colorectal cancer, proliferation, angiogenesis, metastasis Received: May 20, 2016     Accepted: November 12, Published: 24, 2016 ABSTRACT Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation lncRNA transcription can provide signals malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, RNA. Recent studies demonstrated dysregulation is influential metastasis, invasion, apoptosis, stemness, genome instability (CRC), consequent clinical implications. In review, we explicate roles different CRC, potential implications for their application.