ERCC1 codon 118 C→T polymorphism associated with ERCC1 expression and outcome of FOLFOX‐4 treatment in Asian patients with metastatic colorectal carcinoma

摘要: We analyzed the influence of codon 118 CT polymorphism ERCC1 on its protein expression levels, clinicopathological features, and outcome 168 Chinese patients with metastatic colorectal carcinoma that had been treated first-line FOLFOX-4 chemotherapy. A high prevalence C/C genotype was noted (47.6%, n = 80; in total). marked increase levels also C/T or T/T genotypes (70%vs 20%; P < 0.01), which associated significantly lower response to (36.4%vs 57.5%; p = 0.01), shorter progression-free (7 months vs 13 months; P < 0.01) overall (16 months 25 months; survival times. By multivariate analysis, this identified as an independent prognostic factor (P = 0.02). These data suggest Asian populations have a higher 118, could be key determinant for good responses oxaliplatin-based treatment favorable outcomes. (Cancer Sci 2009; 100: 278–283)