Regulation of psychostimulant-induced preprodynorphin, c-fos and zif/268 messenger RNA expression in the rat dorsal striatum by mu opioid receptor blockade

摘要: Several studies have shown that psychostimulants can induce differential immediate early gene and neuropeptide expression in the patch versus matrix compartments of dorsal striatum. The compartment contains a high density mu opioid receptors activation these may contribute to psychostimulant-induced However, contribution receptor changes striatum has not been examined. current study examined role psychostimulant induction preprodynorphin, c-fos zif/268 messenger RNA Male Sprague-Dawley rats were treated with antagonist, clocinnamox (1 mg/kg, s.c.), 24 h prior treatment cocaine (30 i.p.) or methamphetamine (15 s.c.) sacrificed 45 min 3 later. Mu antagonism blocked preprodynorphin only rostral compartment, whereas was attenuated throughout Clocinnamox pretreatment had no effect on stimulant-induced increases expression. These data suggest plays specific