Synergistic effect of interleukin-2 and a vaccine of irradiated melanoma cells transfected to secrete staphylococcal enterotoxin A

摘要: We have previously reported that immunization of mice with melanoma cells transfected to secrete the superantigen, Staphylococcal enterotoxin A (SEA), increased production antibodies B700 antigen, stimulated endogenous interleukin 2 (IL-2), activated expression CD4, CD8 and CD25 T cell markers enhanced NK activity. Now we show a vaccine irradiated sea-transfected coupled IL-2 therapy was even more effective in inhibiting growth primary tumors development lung metastases than alone or alone. The morphological immunological effectiveness dose-dependent on IL-2.