Growth hormone deficiency, low levels of adiponectin, and unfavorable plasma lipid and lipoproteins

摘要: Objective To examine the impact of adolescent growth hormone deficiency (GHD) on circulating adiponectin levels and relation between adiponectin, fasting insulin, plasma lipid, lipoprotein levels. Study design Twelve children with GHD GH treatment a chronological age (CA) 14.4 2.0 years 12 untreated adolescents CA 14.9 2.3 were studied. Adiponectin concentrations measured in all patients, association total, LDL, HDL cholesterol, triglycerides, apolipoprotein A-1, B was evaluated. healthy served as control subjects. Results significantly lower than treated subjects or (P < .008). Total LDL Apo increased adolescents, whereas cholesterol similar three groups. Insulin when compared .05) but to those GHD. found be negatively associated body mass index, waist-to-hip ratio, B, total positive correlation noted both correlated inversely insulin adolescents. Conclusions adolescence is low an unfavorable lipid profile. Our data suggest that may improve abnormalities seen. (J Pediatr 2006;149:324-9)