THE STUDY ON RELATIONSHIP BETWEEN CIGARETTE SMOKING AND THE p53 PROTEIN AND P21 PROTEIN EXPRESSION IN NON-SMALL LUNG CANCER
作者： Zhou Baosen , He Anguang , Zhu Jijiang , Wang Enhua
DOI: 10.1007/BF02675486
关键词:
摘要: This paper discusses the relationship between cigarette smoking and p53 protein P21 expression by immunohistochemical analysis in 93 cases with lung cancer which squamous cell carcinoma accounted for 45 cases, adenocarcinoma 48 cases. The results showed that positive proportion of was 74.20% (28 37 carcinoma, 21 30 adenocarcinomas) group cancers, 38.46% (3 8 7 18 nonsmoking cancers. difference statistically significant. Odds ratio 4.14 confidence limits OR 1.42-12.52. A dose-related presents amount years. 79.31% (21 28 25 82.75% (10 11 squamous, 14 not But their were very high both groups. It indicated no expression. We suggest gene could be a common target tobacco-associated carcinogenesis cancer.
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T Mitsudomi, Seth M Steinberg, Marion M Nau, David Carbone, Domenico D'Amico, Sara Bodner, Herbert K Oie, R Ilona Linnoila, James L Mulshine, John D Minna, None, p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. ,vol. 7, pp. 171- 180 ,(1992)
S. Rodenhuis, S. S. Wagenaar, W. J. Mooi, A. J. M. Boot, R. J. C. Slebos, P. C. Van Bodegom, S. G. Evers, J. L. Bos, Incidence and Possible Clinical Significance of K- ras Oncogene Activation in Adenocarcinoma of the Human Lung Cancer Research. ,vol. 48, pp. 5738- 5741 ,(1988)
K.H. Vahakangas, R.A. Metcalf, J.A. Welsh, W.P. Bennett, C.C. Harris, J.M. Samet, D.P. Lane, Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners The Lancet. ,vol. 339, pp. 576- 580 ,(1992) , 10.1016/0140-6736(92)90866-2
T Takahashi, M. Nau, I Chiba, M. Birrer, R. Rosenberg, M Vinocour, M Levitt, H Pass, A. Gazdar, J. Minna, p53: a frequent target for genetic abnormalities in lung cancer Science. ,vol. 246, pp. 491- 494 ,(1989) , 10.1126/SCIENCE.2554494
Bao-sen Zhou, An-guang He, Tian-jue Wang, The relationship between histologic types of lung cancer and cigarette smoking Lung Cancer. ,vol. 14, ,(1996) , 10.1016/S0169-5002(96)90260-3
Robert J. C. Slebos, Ralph H. Hruban, Otilia Dalesio, Wolter J. Mooi, G. Johan A. Offerhaus, Sjoerd Rodenhuis, Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. Journal of the National Cancer Institute. ,vol. 83, pp. 1024- 1027 ,(1991) , 10.1093/JNCI/83.14.1024
Joyce J. F. J. Bos, ras Oncogenes in Human Cancer: A Review Cancer Research. ,vol. 49, pp. 4682- 4689 ,(1989)
YU-TANG GAO, WILLIAM J BLOT, WEI ZHENG, JOSEPH F FRAUMENI, CHENG-WEN HSU, Lung Cancer and Smoking in Shanghai International Journal of Epidemiology. ,vol. 17, pp. 277- 280 ,(1988) , 10.1093/IJE/17.2.277
Dosaka-Akita Hirotoshi, Masanobu Shindoh, Michihiro Fujino, Ichiro Kinoshita, Kenji Akie, Masakazu Katoh, Yoshikazu Kawakami, Abnormal p53 expression in human lung cancer is associated with histologic subtypes and patient smoking history. American Journal of Clinical Pathology. ,vol. 102, pp. 660- 664 ,(1994) , 10.1093/AJCP/102.5.660