SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression
作者： Lieven Huang , Lea Olive Tchouate Gainkam , Vicky Caveliers , Chris Vanhove , Marleen Keyaerts
DOI: 10.1007/S11307-008-0133-8
关键词:
摘要: Purpose Overexpression of the epidermal growth factor receptor (EGFR) occurs with high incidence in various carcinomas. The oncogenic expression has been exploited for immunoglobulin-based diagnostics and therapeutics. We describe use a llama single-domain antibody fragment, termed Nanobody®, vivo radioimmunodetection EGFR overexpressing tumors using single photon emission computed tomography (SPECT) mice.
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