Human transforming growth factor- α causes precocious eyelid opening in newborn mice
作者： Joseph M. Smith , Michael B. Sporn , Anita B. Roberts , Rik Derynck , Marjorie E. Winkler
DOI: 10.1038/315515A0
关键词: Gene expression 、 Cell biology 、 Malignant transformation 、 Endocrinology 、 In vitro 、 Cancer cell 、 Autocrine signalling 、 Internal medicine 、 Epidermal growth factor 、 Biology 、 Growth factor 、 Transforming growth factor
摘要: Both murine and human epidermal growth factors (EGFs) are known to cause precocious opening of the eyelids in newborn mice. Another set peptides that structurally functionally homologous EGFs type-alpha transforming (TGF-alpha s), TGF-alpha s have been found many cancer cells it has suggested their autocrine action may play an important part malignant transformation. In several vitro systems interchangeable with EGFs. However, vivo activity not characterized, as only small amounts these were available until recently. The cloning gene for its expression Escherichia coli now allow us demonstrate is active EGF promoting eyelid Furthermore, we show a dose-dependent assay potent homologue respect this biological property.
harvard.edu
nature.com
sci-hub.se 参考文章(18)
Morley D. Hollenberg, Epidermal Growth Factor-Urogastrone, a Polypeptide Acquiring Hormonal Status* Vitamins and Hormones Series. ,vol. 37, pp. 69- 110 ,(1980) , 10.1016/S0083-6729(08)61068-7
H Marquardt, G J Todaro, Human transforming growth factor. Production by a melanoma cell line, purification, and initial characterization. Journal of Biological Chemistry. ,vol. 257, pp. 5220- 5225 ,(1982) , 10.1016/S0021-9258(18)34658-1
C. Richard Savage, Stanley Cohen, Epidermal Growth Factor and a New Derivative Journal of Biological Chemistry. ,vol. 247, pp. 7609- 7611 ,(1972) , 10.1016/S0021-9258(19)44568-7
Stanley Cohen, Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal Journal of Biological Chemistry. ,vol. 237, pp. 1555- 1562 ,(1962) , 10.1016/S0021-9258(19)83739-0
R K Assoian, A Komoriya, C A Meyers, D M Miller, M B Sporn, Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. Journal of Biological Chemistry. ,vol. 258, pp. 7155- 7160 ,(1983) , 10.1016/S0021-9258(18)32345-7
Mario A. Anzano, Anita B. Roberts, Lois C. Lamb, Michael B. Sporn, Joseph M. Smith, Chester A. Meyers, Akira Komoriya, Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer Research. ,vol. 42, pp. 4776- 4778 ,(1982)
J Massagué, Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells. Journal of Biological Chemistry. ,vol. 258, pp. 13606- 13613 ,(1983) , 10.1016/S0021-9258(17)43958-5
H. GREGORY, Isolation and structure of urogastrone and its relationship to epidermal growth factor Nature. ,vol. 257, pp. 325- 327 ,(1975) , 10.1038/257325A0
H Marquardt, M. Hunkapiller, L. Hood, G. Todaro, Rat transforming growth factor type 1: structure and relation to epidermal growth factor Science. ,vol. 223, pp. 1079- 1082 ,(1984) , 10.1126/SCIENCE.6320373
S. Cohen, G. Carpenter, Human epidermal growth factor: isolation and chemical and biological properties Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 1317- 1321 ,(1975) , 10.1073/PNAS.72.4.1317