Influences on the density of beta-adrenergic receptors in the cornea and iris--ciliary body of the rabbit.
作者： K A Zawistowski , A H Neufeld , B B Bromberg , E D Page
DOI:
关键词:
摘要: By measurement of the specific binding 3H-dihydroalprenolol, densities beta-adrenergic receptors on membranes prepared from homogenized corneas and iris--ciliary bodies rabbits were studied. Sympathetic denervation, as a result subconjunctival treatment with 6-hydroxydopamine, causes an increase in density ipsilateral body but not cornea. Topical epinephrine for 5 days decrease cornea iris-ciliary body, whereas similar timolol receptors. In cornea, receptor that occurs following vivo is associated decreased ability to synthesize cyclic AMP, altered AMP. Our results indicate anterior segment eye inversely related level adrenergic stimulation tissue AMP does necessarily parallel change density.
arvojournals.org参考文章(22)
J. A. Zadunaisky, S. D. Klyce, A. H. Neufeld, The activation of chloride transport by epinephrine and Db cyclic-AMP in the cornea of the rabbit. Investigative Ophthalmology & Visual Science. ,vol. 12, pp. 127- 139 ,(1973)
A H Neufeld, E D Page, In vitro determination of the ability of drugs to bind to adrenergic receptors. Investigative Ophthalmology & Visual Science. ,vol. 16, pp. 1118- 1124 ,(1977)
M L Sears, A H Neufeld, Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye. Investigative Ophthalmology & Visual Science. ,vol. 14, pp. 688- 689 ,(1975)
Marvin L. Sears, Arthur H. Neufeld, Cyclic-AMP in ocular tissues of the rabbit, monkey, and human. Investigative Ophthalmology & Visual Science. ,vol. 13, pp. 475- 477 ,(1974)
M L Sears, D K Dueker, T Vegge, A H Neufeld, Adenosine 3',5'-monophosphate increases the outflow of aqueous humor from the rabbit eye. Investigative Ophthalmology & Visual Science. ,vol. 14, pp. 40- 42 ,(1975)
J. A. Zadunaisky, A. H. Neufeld, M. Chalfie, Action of epinephrine and other cyclic AMP-mediated agents on the chloride transport of the frog cornea. Investigative Ophthalmology & Visual Science. ,vol. 11, pp. 644- 650 ,(1972)
I M Katz, A L Gould, W A Hubbard, A J Getson, Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Investigative Ophthalmology & Visual Science. ,vol. 15, pp. 489- 492 ,(1976)
Alton L. Steiner, Charles W. Parker, David M. Kipnis, Radioimmunoassay for Cyclic Nucleotides I. PREPARATION OF ANTIBODIES AND IODINATED CYCLIC NUCLEOTIDES Journal of Biological Chemistry. ,vol. 247, pp. 1106- 1113 ,(1972) , 10.1016/S0021-9258(19)45621-4
C Mukherjee, M G Caron, M Coverstone, R J Lefkowitz, Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. Journal of Biological Chemistry. ,vol. 250, pp. 4869- 4876 ,(1975) , 10.1016/S0021-9258(19)41249-0
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)