Expression of a B‐cell marker, CD24, on nasopharyngeal carcinoma cells
作者： Lorainc Karran , Michael Jones , Gary Morley , Susan Van Noorden , Paul Smith
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摘要: Random sequencing of clones from a lambda gt10 cDNA library, made mRNA expressed in an Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) has revealed the gene transcript human CD24. The CD24 antigen, glycosylphosphatidylinositol-anchored cell surface molecule, been identified as B-cell marker that is lost during maturation. We show here it on 3 NPC xenografts, previously defined consisting poorly differentiated epithelial cells, and biopsy. In case former, level expression corresponds to EBV load. A B-lymphoblastoid line carrying same genome one tumours, C15, EBV-negative Burkitt's lymphoma do not display but epithelial-like cells laryngeal tumour (Hep2) express it. Our data suggest may be differentiation only for B also have indirect association with expression.
sci-hub.se 参考文章(22)
M.M. Hitt, M.J. Allday, T. Hara, L. Karran, M.D. Jones, P. Busson, T. Tursz, I. Ernberg, B.E. Griffin, EBV gene expression in an NPC-related tumour. The EMBO Journal. ,vol. 8, pp. 2639- 2651 ,(1989) , 10.1002/J.1460-2075.1989.TB08404.X
E. S. Jaffe, S. M. Hsu, Phenotypic expression of B-lymphocytes. 1. Identification with monoclonal antibodies in normal lymphoid tissues. American Journal of Pathology. ,vol. 114, pp. 387- 395 ,(1984)
M Cordier, A Calender, M Billaud, U Zimber, G Rousselet, O Pavlish, J Banchereau, T Tursz, G Bornkamm, G M Lenoir, Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23. Journal of Virology. ,vol. 64, pp. 1002- 1013 ,(1990) , 10.1128/JVI.64.3.1002-1013.1990
F Wang, C Gregory, C Sample, M Rowe, D Liebowitz, R Murray, A Rickinson, E Kieff, Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. Journal of Virology. ,vol. 64, pp. 2309- 2318 ,(1990) , 10.1128/JVI.64.5.2309-2318.1990
R Kay, R K Humphries, P M Rosten, CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. Journal of Immunology. ,vol. 147, pp. 1412- 1416 ,(1991)
P Busson, R McCoy, R Sadler, K Gilligan, T Tursz, N Raab-Traub, Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma. Journal of Virology. ,vol. 66, pp. 3257- 3262 ,(1992) , 10.1128/JVI.66.5.3257-3262.1992
P R Smith, Y Gao, L Karran, M D Jones, D Snudden, B E Griffin, Complex nature of the major viral polyadenylated transcripts in Epstein-Barr virus-associated tumors. Journal of Virology. ,vol. 67, pp. 3217- 3225 ,(1993) , 10.1128/JVI.67.6.3217-3225.1993
R Bataille, C Boucheix, C Duperray, J Brochier, B Klein, J F Cantaloube, J M Boiron, D Maraninchi, M Attal, T Lavabre-Bertrand, The CD24 antigen discriminates between pre-B and B cells in human bone marrow. Journal of Immunology. ,vol. 145, pp. 3678- 3683 ,(1990)
Robin Fåhraeus, Hu Li Fu, Ingemar Ernberg, Jurgen Finke, Martin Rowe, George Klein, Kerstin Falk, Ethel Nilsson, Manmohan Yadav, Pierre Busson, Thomas Tursz, Bengt Kallin, Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma. International Journal of Cancer. ,vol. 42, pp. 329- 338 ,(1988) , 10.1002/IJC.2910420305
Uwe Zangemeister-Wittke, Hans-Peter Lehmann, Robert Waibel, Edward J. Wawrzynczak, Rolf A. Stahel, Action of a CD24-specific deglycosylated ricin-A-chain immunotoxin in conventional and novel models of small-cell-lung-cancer xenograft. International Journal of Cancer. ,vol. 53, pp. 521- 528 ,(1993) , 10.1002/IJC.2910530327