P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells
作者： Henry W.-C. Leung , M.-J. Hour , W.-T. Chang , Y.-C. Wu , M.-Y. Lai
DOI: 10.1016/J.FCT.2008.08.022
关键词:
摘要: Abstract Photodynamic therapy (PDT) is an effective for local malignant tumors. Lonicera japonica was found to have the anti-tumor effect. The aim of this study explore mechanisms apoptosis induced by PDT in lung CH27 carcinoma cells with alcohol extract from as photosensitizer. Our indicated that extracts exhibited significant photocytotoxicity at a concentration range 50–150 μg/ml, 0.4–1.2 J/cm2 light dose. extracts-induced cell death typical accompanied DNA condensation, externalization phosphatidylserine and formation apoptotic bodies. shown be caspase-3-independent via activation AIF study. P38-associated pathway may involved cells. We also demonstrated probably related its ability change protein expression distribution heat shock 27.
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