Alaska sentinel surveillance for antimicrobial resistance in Helicobacter pylori isolates from Alaska native persons, 1999-2003.

摘要: Background:  Previous studies in Alaska have demonstrated elevated proportions of antimicrobial resistance among Helicobacter pylori isolates. Materials and Methods:  We analyzed H. pylori data from the Centers for Disease Control Prevention (CDC)'s sentinel surveillance July 1999 to June 2003 determine proportion culture-positive biopsies Native persons undergoing routine upper-endoscopy, susceptibility isolates metronidazole [minimum inhibitory concentration (MIC) > 8 g metronidazole/mL), clarithromycin (MIC ≥ 1), tetracycline (MIC ≥ 2) amoxicillin (MIC ≥ 1)] using agar dilution. Results:  Nine-hundred sixty-four biopsy specimens were obtained 687 participants; 352 (51%) patients tested culture positive. Mean age both culture-negative was 51 years. Metronidazole 155 (44%) persons, 108 (31%) 8 (2%) 0 resistance. varied by geographic region. Female more likely than male subjects show (p < .01) (p = .05). Conclusions:  Resistance is common when compared with those elsewhere USA.