Insulin receptors, receptor antibodies, and the mechanism of insulin action.

摘要: Publisher Summary Insulin exerts a wide spectrum of effects at the cellular level. These include membrane level, for example, stimulation glucose and amino acid uptake; on both cytoplasmic enzymes; protein synthesis, DNA cell growth, differentiation. This is reason why unraveling mechanism insulin action has been difficult. chapter describes receptors, receptor antibodies, action. In addition, vary in time course dose–response. Some insulin, such as transport, occur within seconds after hormone exposure, whereas others, require hours; most enzymes lie somewhere between these two extremes. It well known that stimulates this effect persists vesicles even broken. Several new probes have become available shed some light problem cultured systems, which are highly responsive to insulin; methods studying structure; mutant lines possess defects either or pathways action; antibodies block binding mimic