Analysis of Germline and Expressed T Cell Receptor Variable Region Genes in Crohn's Disease
作者： C. Thurley , B. Salh , W. Kwan , H. Freeman , C. Blake Gilks
DOI: 10.1016/S0344-0338(96)80044-6
关键词:
摘要: Summary A possible role of the T cell receptor genes in pathogenesis Crohn's disease was investigated by 1) comparison restriction fragment length polymorphisms at s chain locus 64 patients and normal controls; 2) semiquantitative polymerase reaction analysis a variable region gene expression lamina propria lymphocytes from resected segments diseased terminal ileum. We found no association between any using polymorphic markers spanning locus. Analysis Vs Va showed that V families ileum with active indistinguishable These data fail to support susceptibility being associated antigen genotype. No restricted or dominant tissue, compared
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