Diarrhea caused by Escherichia coli that produce only heat-stable enterotoxin.

摘要: To determine the role of Escherichia coli heat-stable enterotoxin (ST) as a virulence factor in human diarrhea, strain that elaborates only ST (E. 214-4) was fed to free-living volunteers doses 10(6), 10(8), and 10(10) organisms. Short-lived (1 day) mild illness consisting abdominal cramps with vomiting or diarrhea occurred three five individuals 10(8). Typical travelers' (loose stools, cramps, low-grade fever for 2 3 days) seen four given 10(10); two had brief cholera-like purging rice-water stools. Despite fever, there no evidence mucosal invasion. E. 214-4 became predominant coliform stools; coproculture isolates were uniformly negative heat-labile (LT), whereas most produced ST. Ten 13 developed rises antibody somatic antigen, none LT antitoxin. elaborate can cause diarrheal disease adults.