Controlling invasive rodents via synthetic gene drive and the role of polyandry

摘要: House mice are a major ecosystem pest, particularly threatening island ecosystems as non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation. Recently, sperm-killing gene drive construct called t-Sry has been proposed means eradicate target mouse populations owing lack of females. A factor that received little attention the discussion surrounding such applications is polyandry. Previous research demonstrated drivers extremely damaging male's sperm competitive ability. Here, we examine importance this effect on system using theoretical model. We find polyandry substantially hampers spread release efforts have be increased three- sixfold successful eradication. discuss implications our finding potential programmes, risk beyond population, and emergence resistance. Our work highlights solid understanding forces determine dynamics natural setting key application, exploring diversity drives may inform effective design.