CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.

摘要: CHCHD2 was identified a novel cell migration-promoting gene, which could promote migration and altered adhesion when ectopically overexpressed in NIH3T3 fibroblasts, it as protein necessary for OxPhos function well. However, the clinic relevance of expression NSCLC remains unclear. Here we assumed that would accompanies HIF-1α to response hypoxia occurrence NSCLC. In order verify this hypothesis, correlations among levels were detected analyzed 209 pair cases The location these molecules assessed using Immunohistochemistry, immunohistofluorescence, qRT-PCR western blotting. differences two with clinical pathological characteristics statistically Wilcoxon (W) text, Mann-Whitney U, Kruskal-Wallis H cross-table tests. Kaplan-Meier survival analysis Cox proportional hazards models used estimate effect on patients’ survival. Data showed higher than normal tissues (all P = 0.000). significantly related smoking, tumor size, differentiation degree, TNM Stage, lymph metastasis P 0.3). Immunohistofluorescence there co-localization phenomenon cytoplasm nucleus between expression. patients had worse prognosis those lower P = 0.0001; log-rank test). multivariate indicated an independent prognostic factor (hazard ratio [HR], 0.492, P = 0.001). Our results indicate over-expression adapt microenviroment serves biomarker