Characteristics of different mesh types for abdominal wall repair in an experimental model of peritonitis

摘要: Background The use of synthetic mesh to repair a potentially contaminated incisional hernia may lead higher failure rates. A biological might be considered, but little is known about long-term results. Both and meshes were investigated in an experimental model peritonitis assess their characteristics vivo. Methods Male Wistar rats randomized into five groups was induced. implanted after 24 h. Five investigated: Permacol™ (cross-linked collagen), Strattice™ (non-cross-linked XCM Biologic® Omyra® Mesh (condensed polytetrafluoroethylene) Parietene™ (polypropylene). The killed either 30, 90 or 180 days. Incorporation shrinkage the mesh, adhesion coverage, strength adhesions histology analysed. Results Of 135 randomized, 18 died from peritonitis. Some 180 days implantation, both had significantly better incorporation than (P = 0·003 P = 0·009 respectively). fewer (P = 0·001) (P = 0·020). Thirty days stronger (P < 0·001). Shrinkage most prominent Biologic®, no significant difference found compared with other meshes. Histological analysis revealed marked differences foreign body response among all meshes. Conclusion This study suggested that superior terms incorporation, macroscopic infection, histological parameters such as collagen deposition neovascularization. There must sufficient overlap during placement, showed high rate shrinkage. Surgical relevance The not supported unequivocally, rate. considered alternative. are few studies, these expensive rarely used. This evaluated environment, whether there ideal mesh. new non-cross-linked (XCM Biologic®) this experiment. The performed best useful patients hernia.