Multivariable Model for Time to First Treatment in Patients With Chronic Lymphocytic Leukemia

摘要: Purpose The clinical course for patients with chronic lymphocytic leukemia (CLL) is diverse; some have indolent disease, never needing treatment, whereas others aggressive disease requiring early treatment. We continue to use criteria active initiate therapy. Multivariable analysis was performed identify prognostic factors independently associated time first treatment CLL. Patients and Methods Traditional laboratory, prognostic, newer such as fluorescent in situ hybridization (FISH), IGHV mutation status, ZAP-70 expression evaluated at patient visit MD Anderson Cancer Center were correlated by multivariable This model used develop a nomogram—a weighted tool calculate 2- 4-year probability of estimate median Results There 930 previously untreated who had traditional new fa...