Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood
作者： Steven D. Holladay , Shuo Xiao , Honglu Diao , Jamie Barber , Tomas Nagy
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摘要: Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines suggested the adult offspring. Serum showed a numeric increase 16 21 basal levels. ConA-stimulated splenocytes 17 cytokines, and LPS-stimulated an 18 cytokines. The profile was one TH1 up-regulation more than TH2, with skewing toward TH17 responses.
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Osamu Tsutsumi, Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction. The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 93, pp. 325- 330 ,(2005) , 10.1016/J.JSBMB.2004.12.008
S D Holladay, R J Smialowicz, Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure. Environmental Health Perspectives. ,vol. 108, pp. 463- 473 ,(2000) , 10.1289/EHP.00108S3463
Nancy R. Manley, Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation Seminars in Immunology. ,vol. 12, pp. 421- 428 ,(2000) , 10.1006/SMIM.2000.0263
Yelena B. Wetherill, Benson T. Akingbemi, Jun Kanno, John A. McLachlan, Angel Nadal, Carlos Sonnenschein, Cheryl S. Watson, R. Thomas Zoeller, Scott M. Belcher, In vitro molecular mechanisms of bisphenol A action. Reproductive Toxicology. ,vol. 24, pp. 178- 198 ,(2007) , 10.1016/J.REPROTOX.2007.05.010
Wenjun Ouyang, Jay K. Kolls, Yan Zheng, The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation Immunity. ,vol. 28, pp. 454- 467 ,(2008) , 10.1016/J.IMMUNI.2008.03.004
Jo L Eyles, Andrew W Roberts, Donald Metcalf, Ian P Wicks, Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nature Reviews Rheumatology. ,vol. 2, pp. 500- 510 ,(2006) , 10.1038/NCPRHEUM0291
Xiaoqin Ye, Kotaro Hama, James J. A. Contos, Brigitte Anliker, Asuka Inoue, Michael K. Skinner, Hiroshi Suzuki, Tomokazu Amano, Grace Kennedy, Hiroyuki Arai, Junken Aoki, Jerold Chun, LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing Nature. ,vol. 435, pp. 104- 108 ,(2005) , 10.1038/NATURE03505
Jennifer L. Head, B. Paige Lawrence, The aryl hydrocarbon receptor is a modulator of anti-viral immunity Biochemical Pharmacology. ,vol. 77, pp. 642- 653 ,(2009) , 10.1016/J.BCP.2008.10.031
E Karpuzoglu-Sahin, B.D Hissong, S Ansar Ahmed, Interferon-γ levels are upregulated by 17-β-estradiol and diethylstilbestrol Journal of Reproductive Immunology. ,vol. 52, pp. 113- 127 ,(2001) , 10.1016/S0165-0378(01)00117-6
Wade V. Welshons, Susan C. Nagel, Frederick S. vom Saal, Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol A at Levels of Human Exposure Endocrinology. ,vol. 147, ,(2006) , 10.1210/EN.2005-1159