Post-transplantation Cyclophosphamide and Sirolimus after Haploidentical Hematopoietic Stem Cell Transplantation Using a Treosulfan-based Myeloablative Conditioning and Peripheral Blood Stem Cells.
作者： Nicoletta Cieri , Raffaella Greco , Lara Crucitti , Mara Morelli , Fabio Giglio
DOI: 10.1016/J.BBMT.2015.04.025
关键词:
摘要: Abstract Haploidentical hematopoietic stem cell transplantation (HSCT) performed using bone marrow (BM) grafts and post-transplantation cyclophosphamide (PTCy) has gained much interest for the excellent toxicity profile after both reduced-intensity myeloablative conditioning. We investigated, in a cohort of 40 high-risk hematological patients, feasibility peripheral blood cells treosulfan-melphalan conditioning, followed by PTCy sirolimus-based graft-versus-host disease (GVHD) prophylaxis (Sir-PTCy). Donor engraftment occurred all with full donor chimerism achieved day 30. Post-HSCT recovery lymphocyte subsets was broad fast, median time to CD4 > 200/μL 41 days. Cumulative incidences grade II IV III-IV acute GVHD were 15% 7.5%, respectively, associated significant early increase circulating regulatory T at 15 HSCT, values
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