Targeted mini-strokes produce changes in interhemispheric sensory signal processing that are indicative of disinhibition within minutes

摘要: Most processing of sensation involves the cortical hemisphere opposite (contralateral) to stimulated limb. Stroke patients can exhibit changes in interhemispheric balance sensory signal processing. It is unclear whether these are result poststroke rewiring and experience, or they could from immediate effect circuit loss. We evaluated mini-strokes over short timescales (<2 h) where unlikely by monitoring sensory-evoked activity throughout much both hemispheres using voltage-sensitive dye imaging. Blockade a single pial arteriole within C57BL6J mouse forelimb somatosensory cortex reduced response evoked stimulation limb contralateral stroke. However, after stroke, ipsilateral (uncrossed) unaffected was spared became independent cortex. Within hemisphere, significantly enhanced responses produced either pathways 30–50 min stroke onset. Stroke-induced enhancement not reproduced inhibition thalamus pharmacological agents nonischemic animals. I/LnJ acallosal mice showed similar rapid redistribution suggesting that subcortical connections transcallosal projections were mediating novel activation patterns. Thalamic inactivation before prevented bilateral rearrangement responses. These findings suggest acute merely loss activity, activates unique rapidly redistribute function hemisphere.