Distribution and origin of bovine major histocompatibility complex class II DQA1 genes in Japan

作者: S. Takeshima , S. Chen , M. Miki , M. Kado , Y. Aida

DOI: 10.1111/J.1399-0039.2008.01092.X

关键词:

摘要: We sequenced the major histocompatibility complex (MHC) class II DQA1 gene in 352 Japanese cattle (95 Black, 91 Holstein, 102 Shorthorn and 64 Jersey cattle) using a new sequence-based typing method. In total, 19 bovine MHC (BoLA)-DQA1 alleles, of which two were novel detected. The Jersey, Black breeds had 13, 12, 10 15 respectively. dendrogram that was constructed by neighbor-joining method on basis allele frequencies four showed Holstein closest to each other, with being farther from these than Shorthorn. addition, Wu-Kabat analysis alleles most least polymorphic, Phylogenetic analyses indicated Bovidae such as cattle, sheep, bison goat more similar pig SLA-DQA genes human HLA-DQA1 dog DLA-DQA genes. goat, bison, molecules rates amino acid sequence polymorphism, but distribution their polymorphic residues differed protein. However, molecule human, DQA at regions, namely positions 52-53 65-66. This indicates locus is loci other species.

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