Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

摘要: Two forms of activated BCR/ABL proteins, P210 and P185, that differ in BCR-derived sequences, are associated with Philadelphia chromosome-positive leukemias. One these diseases is chronic myelogenous leukemia, an indolent disease arising hematopoietic stem cells almost always the form BCR/ABL. Acute lymphocytic a more aggressive malignancy, can be both While it virtually certain plays central role diseases, features determine association particular given have not been elucidated. We used bone marrow reconstitution leukemogenesis model to test hypothesis BCR sequences influence ability ABL transform different types cells. Our studies reveal P185 induce similar spectrum hematological including granulocytic, myelomonocytic, Despite similarity patterns, animals P185-infected developed after shorter latent period than those P210-infected marrow. These data demonstrate structure oncoprotein does affect type induced by each oncogene but control potency oncogenic signal.