Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin
作者： Duo Wu , Wei Wen , Chun-Li Qi , Ru-Xia Zhao , Jun-Hua Lü
DOI: 10.1016/J.PHYMED.2012.03.003
关键词:
摘要: Berberine (BBR) is one of the main constituents in Rhizoma coptidis and it has widely been used for treatment diabetic nephropathy. The aims study were to investigate effects mechanism action berberine on renal damage rats. Diabetes hyperglycaemia induced rats by a high-fat diet intraperitoneal injection 40 mg/kg streptozotocin (STZ). Rats randomly divided into 5 groups, such as i) control rats, ii) untreated iii) 250 metformin-treated, iv v) 100 200 berberine-treated treated separately 8 weeks. fasting blood glucose, insulin, total cholesterol, triglyceride, glycosylated hemoglobin measured Kidneys isolated at end histology, Western blot analysis estimation malonaldehyde (MDA), superoxide dismutase (SOD) advanced glycation endproducts (AGEs). results revealed that significantly decreased insulin levels, triglyceride urinary protein excretion, serum creatinine (Scr) urea nitrogen (BUN) histological examinations amelioration diabetes-induced glomerular pathological changes following with berberine. In addition, expressions nephrin podocin increased. It seems likely exerts an ameliorative effect diabetes streptozotocin. possible mechanisms renoprotective may be related inhibition glycosylation improvement antioxidation turn upregulate podocin.
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sci-hub.se 参考文章(32)
Schrier Rw, Estacio Ro, Diabetic nephropathy: pathogenesis, diagnosis, and prevention of progression. Advances in internal medicine. ,vol. 46, pp. 359- 408 ,(2001)
Wei-hua LIU, Zi-qing HEI, Hong NIE, Fu-tian TANG, He-qing HUANG, Xue-juan LI, Yan-hui DENG, Shao-rui CHEN, Fen-fen GUO, Wen-ge HUANG, Feng-ying CHEN, Pei-qing LIU, Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chinese Medical Journal. ,vol. 121, pp. 706- 712 ,(2008) , 10.1097/00029330-200804020-00009
Séverine Roselli, Imane Moutkine, Olivier Gribouval, Alexandre Benmerah, Corinne Antignac, Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations. Traffic. ,vol. 5, pp. 37- 44 ,(2004) , 10.1046/J.1600-0854.2003.00148.X
Chunhua Zhu, Songming Huang, Yanggang Yuan, Guixia Ding, Ronghua Chen, Bicheng Liu, Tianxin Yang, Aihua Zhang, Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage: A Therapeutic Target of PPARγ American Journal of Pathology. ,vol. 178, pp. 2020- 2031 ,(2011) , 10.1016/J.AJPATH.2011.01.029
Edward C. Dempsey, Alexandra C. Newton, Daria Mochly-Rosen, Alan P. Fields, Mary E. Reyland, Paul A. Insel, Robert O. Messing, Protein kinase C isozymes and the regulation of diverse cell responses American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 279, ,(2000) , 10.1152/AJPLUNG.2000.279.3.L429
Qingfeng Fan, Jie Ding, Jingjing Zhang, Na Guan, Jianghong Deng, Effect of the Knockdown of Podocin mRNA on Nephrin and α-Actinin in Mouse Podocyte Experimental Biology and Medicine. ,vol. 229, pp. 964- 970 ,(2004) , 10.1177/153537020422900914
Anabela P. Rolo, Carlos M. Palmeira, Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicology and Applied Pharmacology. ,vol. 212, pp. 167- 178 ,(2006) , 10.1016/J.TAAP.2006.01.003
Daisuke Fukudome, Maki Matsuda, Toshiyuki Kawasaki, Yukio Ago, Toshio Matsuda, The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice European Journal of Pharmacology. ,vol. 583, pp. 164- 169 ,(2008) , 10.1016/J.EJPHAR.2008.01.033
Takuma Narita, Jun Koshimura, Katsunori Suzuki, Masahiko Murata, Hiroyuki Meguro, Hiroki Fujita, Hiroji Kitazato, Seiki Ito, Effects of short-term glycemic control, low protein diet and administration of enalapril on renal hemodynamics and protein permselectivity in type 2 diabetic patients with microalbuminuria. Tohoku Journal of Experimental Medicine. ,vol. 189, pp. 117- 133 ,(1999) , 10.1620/TJEM.189.117
Wawaimuli Arozal, Kenichi Watanabe, Punniyakoti T. Veeraveedu, Meilei Ma, Rajarajan A. Thandavarayan, Vijayakumar Sukumaran, Kenji Suzuki, Makoto Kodama, Yoshifusa Aizawa, Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats Toxicology. ,vol. 274, pp. 18- 26 ,(2010) , 10.1016/J.TOX.2010.05.003