P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

作者: M. Yamakuchi , C. D. Lotterman , C. Bao , R. H. Hruban , B. Karim

DOI: 10.1073/PNAS.0911082107

关键词:

摘要: … p53 also can regulate hypoxic signaling by unknown pathways, we hypothesized that miRNA can mediate p53 regulation of tumor angiogenesis. … /miR-107 that mediate p53 induction, …

参考文章(43)
Andrew L. Kung, Stream Wang, Jeffery M. Klco, William G. Kaelin, David M. Livingston, Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Medicine. ,vol. 6, pp. 1335- 1340 ,(2000) , 10.1038/82146
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
Bert Vogelstein, David Lane, Arnold J. Levine, Surfing the p53 network Nature. ,vol. 408, pp. 307- 310 ,(2000) , 10.1038/35042675
H. Zhu, H. F. Bunn, SIGNAL TRANSDUCTION: How Do Cells Sense Oxygen? Science. ,vol. 292, pp. 449- 451 ,(2001) , 10.1126/SCIENCE.1060849
Mikhail V. Blagosklonny, Won G. An, Larisa Y. Romanova, Jane Trepel, Tito Fojo, Len Neckers, p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription * Journal of Biological Chemistry. ,vol. 273, pp. 11995- 11998 ,(1998) , 10.1074/JBC.273.20.11995
Louis M. Sherwood, Edith E. Parris, Judah Folkman, Tumor Angiogenesis: Therapeutic Implications New England Journal of Medicine. ,vol. 285, pp. 1182- 1186 ,(1971) , 10.1056/NEJM197111182852108
Napoleone Ferrara, None, VEGF and the quest for tumour angiogenesis factors Nature Reviews Cancer. ,vol. 2, pp. 795- 803 ,(2002) , 10.1038/NRC909
William G. Kaelin, Peter J. Ratcliffe, Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway Molecular Cell. ,vol. 30, pp. 393- 402 ,(2008) , 10.1016/J.MOLCEL.2008.04.009